i have same messages with a 650 cluster running 10.0R2.10. also saw them with 10.0R1.8.
as far as i can tell right now, the gencfg messages are from something during a commit.
just before these errors, i have:
Jan 27 10:41:41 init: can not access /usr/sbin/ipmid: No such file or directory
Jan 27 10:41:41 init: ipmi (PID 0) started
Jan 27 10:41:43 /kernel: GENCFG: op 2 (Gencfg Blob) failed; err 7 (Doesn't Exist)
Jan 27 10:41:43 /kernel: GENCFG: op 2 (Gencfg Blob) failed; err 7 (Doesn't Exist)
not quite the i2c error, but something similar. maybe part of the reason why my ha light still doesn't work.